ProteinForge
ProteinForgeby Bajpai Labs
Services

Four biologics pipelines. Built for pharma timelines.

Every engagement returns ranked antibody or protein sequences plus the technical documentation your team needs to take work straight into CHO expression and validation.

Service 01

Antibody Discovery

Discovering neutralizing or therapeutic antibodies against viral, oncology, or autoimmune targets with strong developability.

Timeline
3–4 weeks
Starting price
Engagements typically $250K–$550K per program
Process
  1. 01Epitope mapping and antigen structure analysis (PDB or AlphaFold)
  2. 02CDR-H3 enumeration generating million-variant antibody libraries
  3. 03AlphaFold-Multimer binding prediction and neutralization probability scoring
  4. 04Deliver top 50–500 antibodies ranked by affinity, function, and developability
Deliverable
Ranked antibody sequences (FASTA), epitope bin assignments, CHO codon-optimized expression files
Service 02

Protein Design

Engineering enzymes, binders, or scaffolds with improved stability, activity, or expression in production systems.

Timeline
2–3 weeks
Starting price
Engagements typically $200K–$450K per program
Process
  1. 01Structure analysis and functional site mapping (AlphaFold or experimental PDB)
  2. 02ESM-2 mutational scanning and inverse folding for variant generation
  3. 03Thermostability and activity retention prediction via MD simulation
  4. 04Rank top 20–100 variants by stability, activity, and expression probability
Deliverable
Ranked protein variants (FASTA), mutation map, E. coli or yeast codon-optimized sequences
Service 03

Affinity Maturation

Optimizing an existing antibody or protein lead to sub-nM affinity while preserving developability.

Timeline
2–3 weeks
Starting price
Engagements typically $180K–$350K per program
Process
  1. 01Interface analysis of parent antibody-protein complex
  2. 02Targeted CDR or interface mutation campaigns (100K+ variants)
  3. 03Multi-objective ranking by predicted KD improvement and developability retention
  4. 04Deliver top 20–50 matured candidates with affinity and stability predictions
Deliverable
Ranked matured sequences, predicted KD improvements, developability comparison vs. parent
Service 04

Developability Optimization

Fixing aggregation, viscosity, immunogenicity, or expression issues in clinical-stage biologics and bispecifics.

Timeline
3–5 weeks
Starting price
Engagements typically $300K–$650K per program
Process
  1. 01Developability diagnostic on parent sequence (aggregation, viscosity, immunogenicity)
  2. 02Computational remediation via surface engineering, Fc modification, or format redesign
  3. 03Bispecific geometry and CRS risk scoring for T-cell engagers
  4. 04Deliver top 10–30 optimized candidates with full developability dossier
Deliverable
Optimized sequences, developability scorecard, bispecific format comparison (if applicable)
Methodology

The science behind the pipeline.

We compose published, peer-reviewed methods with proprietary biologics scoring trained on our own wet-lab validation data.

Protein language models

ESM-2, ESMFold, and inverse folding for CDR design and stability prediction.

AlphaFold-Multimer

Antibody-antigen and bispecific interface prediction trained on proprietary validation sets.

Molecular dynamics

GROMACS / OpenMM simulations for interface stability and thermostability refinement.

Developability scoring

Aggregation, immunogenicity, viscosity, and CHO expression probability models.

Custom & Enterprise Projects

Bispecific platform development, multi-antigen campaigns, integration with internal sequence databases, and bespoke ML model training on proprietary antibody corpora.

  • Bispecific platform design
  • Integration with client sequence libraries
  • Real-time scientist collaboration
  • Custom developability model training
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